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A New Ring Expansion for a Chiral Hexahydroazulene Skeleton Possessing an Angular Methyl Group

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journal contribution
posted on 19.08.2011, 00:00 by Masaatsu Adachi, Takema Komada, Toshio Nishikawa
A new synthetic route for a pseudoguaiane ring system is described. The synthesis features an Ireland–Claisen rearrangement for constructing the trans-fused ring system, followed by a new ring expansion to yield a bicyclo[5.3.0]decane ring system possessing an angular methyl group.