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A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles

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posted on 2007-05-25, 00:00 authored by Daniel Zewge, Cheng-yi Chen, Curtis Deer, Peter G. Dormer, Dave L. Hughes
The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditionally employed. This cyclization protocol is used to prepare a host of heterocycles and bis-quinolones and is characterized by relatively low reaction temperature and ease of product isolation.

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