1T-Phase Dirac Semimetal PdTe2 Nanoparticles for Efficient Photothermal Therapy in the NIR-II Biowindow
journal contributionposted on 10.06.2021, 18:13 by Jingjing Luo, Mingjian Fan, Liwei Xiong, Qiaoyan Hao, Mengna Jiang, Qianjun He, Chenliang Su
1T-phase transition-metal dichalcogenides (TMDs) nanomaterials are one type of emerging and promising near-infrared II (NIR-II) photothermal agents (PTAs) derived from their distinct metallic electronic structure, but it is still challenging to synthesize these nanomaterials. Herein, PdTe2 nanoparticles (PTNs) with a 1T crystal symmetry and around 50 nm in size are prepared by an electrochemical exfoliation method, and the corresponding photothermal performances irradiated under a NIR-II laser have been explored. The encapsulation of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) (DSPE-PEG) endows PTNs with water solubility, enhanced photothermal stability, and high biocompatibility. Notably, PTN/DSPE-PEG displays a potent absorbance through the NIR-II zone and considerable photothermal conversion efficiency, which is up to 68% when irradiated with a 1060 nm laser. With these unique photothermal properties, excellent in vitro and in vivo tumor inhibition effects of PTN/DSPE-PEG have been achieved under the irradiation of a NIR-II (1060 nm) laser without visible toxicity to normal tissues, suggesting that it is an efficient NIR-II photothermal nanoagent.
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NIR-II Biowindow 1 T-phase transiti...NIR-II laserelectrochemical exfoliation methodphotothermal conversion efficiencyNIR-II zonewater solubilityPTNPTA1 T-Phase Dirac Semimetal PdTe 2 Na...photothermal agentsphotothermal propertiesglycero -3-phosphoethanolamine glycol1060 nm laserTMD1 T crystal symmetryNIR-II photothermal nanoagentPdTe 2 nanoparticlesnear-infrared IIEfficient Photothermal TherapyDSPE-PEGphotothermal performancesvivo tumor inhibition effects50 nmphotothermal stability