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[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum

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journal contribution
posted on 15.04.2016 by Pâmela J. dos S. Beirigo, Heron F. V. Torquato, Carlos H. C. dos Santos, Mário G. de Carvalho, Rosane N. Castro, Edgar J. Paredes-Gamero, Marcos J. Jacinto, Virgínia C. da Silva
A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey’s method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).