Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
journal contributionposted on 16.08.2018 by Dattatraya H. Dethe, Raghavender Boda
Any type of content formally published in an academic journal, usually following a peer-review process.
An efficient synthesis of dimethyl tripartin as a synthetic precursor of natural product tripartin, the first natural specific inhibitor of histone H3 lysine 9 demethylase KDM4, is described. The synthesis of dimethyl tripartin was achieved in a six-step longest linear sequence starting from commercially available 3,5-dimethoxy benzaldehyde with 21% overall yield, using ClTi(OiPr)3-mediated dichloromethine insertion as the key step.