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Synthesis of the Sialic Acid (−)-KDN and Certain Epimers from (−)-3-Dehydroshikimic Acid or (−)-Quinic Acid

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journal contribution
posted on 05.08.2004, 00:00 by Martin G. Banwell, Natasha L. Hungerford, Katrina A. Jolliffe
(−)-3-Dehydroshikimic acid (3-DHS, 4), a C7-building block now available in large quantity from corn syrup, has been converted into the sialic acid (−)-KDN (3) as well as its C-7- and C-8-epimers. (−)-Quinic acid can be used for the same purpose.

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