Synthesis of Tetramic Acid Derivatives via a Tandem Umpolung Alkylation/Reduction/Cyclization Reaction of γ‑Hydrazono β‑Ketoester
journal contributionposted on 31.03.2020 by Isao Mizota, Miki Maeda, Kiho Imoto, Makoto Shimizu
Any type of content formally published in an academic journal, usually following a peer-review process.
An efficient method for the one-pot synthesis of tetramic acid derivatives was developed utilizing tandem umpolung N-alkylation/reduction/cyclization of γ-hydrazono β-ketoester. By using this reaction as a key step, the total synthesis of the 3-spiro 7-hydroxamic acid tetralin which possesses an HDAC inhibitory activity was also achieved.