Synthesis of Saponins Using Partially Protected Glycosyl Donors
journal contributionposted on 29.08.2003 by Yuguo Du, Guofeng Gu, Guohua Wei, Yuxia Hua, Robert J. Linhardt
Any type of content formally published in an academic journal, usually following a peer-review process.
A new class of glycosyl donors having unprotected 2- and 2,4-hydroxyl groups were investigated under the standard glycosylation conditions. This approach was shown to be generally effective for the synthesis of alkyl and steroidal glycosides. A natural saponin, containing 2,4-branched oligosaccharide, was prepared in 35% overall yield in four straightforward sequential reactions by taking advantage of these partially protected donors.