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Synthesis of Saponins Using Partially Protected Glycosyl Donors

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journal contribution
posted on 29.08.2003 by Yuguo Du, Guofeng Gu, Guohua Wei, Yuxia Hua, Robert J. Linhardt
A new class of glycosyl donors having unprotected 2- and 2,4-hydroxyl groups were investigated under the standard glycosylation conditions. This approach was shown to be generally effective for the synthesis of alkyl and steroidal glycosides. A natural saponin, containing 2,4-branched oligosaccharide, was prepared in 35% overall yield in four straightforward sequential reactions by taking advantage of these partially protected donors.

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