Straightforward Synthesis of a Double-Lasso Macrocycle from a Nonsymmetrical [c2]Daisy Chain
journal contributionposted on 20.02.2016 by Camille Romuald, Guillaume Cazals, Christine Enjalbal, Frédéric Coutrot
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The straightforward synthesis of a double-lasso macrocycle from a nonsymmetrical [c2]daisy chain, using the copper(I)-catalyzed Huisgen alkyne–azide 1,3-dipolar cycloaddition, is described. The preparation of the nonsymmetrical alkyne azide [c2]daisy chain precursor was realized in situ via the exchange of the monomers contained in both symmetrical alkyne and azide [c2]daisy chains and was followed by mass spectrometry.