Sensing Organic Amines and Quantitative Monitoring of Intracellular pH Change Using a Fluorescent Self-Assembly System
journal contributionposted on 07.05.2019 by Xinhua Cao, Yiran Li, Aiping Gao, Yongsheng Yu, Xueping Chang, Xiaohan Hei
Any type of content formally published in an academic journal, usually following a peer-review process.
A series of supramolecular self-assembly gelators (N-4, N-12, and N-18) were designed and synthesized. N-12 and N-18 could gelate some single or mixed solvents. Microbelts and nanofibers were obtained in the self-assembly process. The hydrophobic xerogel N-18 film surface had water contact angles of 119–148.5°. Interestingly, these compounds exhibited solvatochromism properties, and compound N-18 had ratiometric detection ability toward organic amines with a detection limit for triethylamine (TEA) of 2.23 × 10–6 M. At the same time, compound N-18 in solution and the organogel state could distinguish aromatic amines and fatty amines through its fluorescence changing. These compounds exhibited a specific pH-dependence fluorescence behavior in the the pH value range of 3–11. Compound N-4 was successfully applied to bioimaging for quantitative monitoring of pH change in cell. This work provides a new window for the preparation of self-assembly for sensitive detection organic amines and pH probes for accurate intracellular pH mapping and quantifying.