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Reverse Fluorous Solid-Phase Extraction:  A New Technique for Rapid Separation of Fluorous Compounds

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journal contribution
posted on 05.08.2004, 00:00 by Masato Matsugi, Dennis P. Curran
Fluorous-tagged compounds can rapidly be separated from organic (non-tagged) compounds by the new separation technique of reverse fluorous solid-phase extraction (r-fspe). In a reversal of the roles of solid and liquid phases in standard fluorous spe, a mixture is charged to a polar solid phase (standard silica gel) and then eluted with a fluorous solvent or solvent mixture. The organic components of the mixture are retained, while the fluorous components pass.