Phenazinium Salt-Catalyzed Aerobic Oxidative Amidation of Aromatic Aldehydes
journal contributionposted on 07.11.2014 by Dasheng Leow
Any type of content formally published in an academic journal, usually following a peer-review process.
Amides are prevalent in organic synthesis. Developing an efficient synthesis that avoids expensive oxidants and heating is highly desirable. Here the oxidative amidation of aromatic aldehydes is reported using an inexpensive metal-free visible light photocatalyst, phenazine ethosulfate, at low catalytic loading (1–2 mol %). The reaction proceeds at ambient temperature and uses air as the sole oxidant. The operationally easy procedure provides an economical, green, and mild alternative for the formation of amide bonds.