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Pd-Catalyzed Aldehyde to Ester Conversion: A Hydrogen Transfer Approach

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journal contribution
posted on 01.02.2013 by Brittany A. Tschaen, Jason R. Schmink, Gary A. Molander
Aliphatic and aromatic aldehydes are successfully converted into their corresponding esters using Pd(OAc)2 and XPhos. This approach utilizes a hydrogen transfer protocol: concomitant reduction of acetone to isopropanol provides an inexpensive and sustainable approach that mitigates the need for other oxidants.