Pd-Catalyzed Aldehyde to Ester Conversion: A Hydrogen Transfer Approach
journal contributionposted on 01.02.2013 by Brittany A. Tschaen, Jason R. Schmink, Gary A. Molander
Any type of content formally published in an academic journal, usually following a peer-review process.
Aliphatic and aromatic aldehydes are successfully converted into their corresponding esters using Pd(OAc)2 and XPhos. This approach utilizes a hydrogen transfer protocol: concomitant reduction of acetone to isopropanol provides an inexpensive and sustainable approach that mitigates the need for other oxidants.