Palladium-Catalyzed Sequential Arylation and Allylic Alkylation of Highly Functionalized Ketones: A Concise Synthesis of Mesembrine
journal contributionposted on 05.02.2009 by Yuanhong Zhao, Yongyun Zhou, Leilei Liang, Xiaodong Yang, Fengxiang Du, Liang Li, Hongbin Zhang
Any type of content formally published in an academic journal, usually following a peer-review process.
An unprecedented palladium-catalyzed sequential procedure toward arylation and allylic alkylation of highly functionalized cyclohexenones was developed. This new protocol leads to useful building blocks containing a benzylic quaternary carbon in only one step. A concise total synthesis of mesembrine based on this procedure was achieved in only five steps with 22% overall yield.