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Palladium-Catalyzed Deaminative Phenanthridinone Synthesis from Aniline via C–H Bond Activation

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journal contribution
posted on 18.04.2016 by Subhash L. Yedage, Bhalchandra M. Bhanage
This work reports palladium-catalyzed phenanthridinone synthesis using the coupling of aniline and amide by formation of C–C and C–N bonds in a one-pot fashion via dual C–H bond activation. It involves simultaneous cleavage of four bonds and the formation of two new bonds. The present protocol is ligand-free, takes place under mild reaction conditions, and is environmentally benign as nitrogen gas and water are the only side products. This transformation demonstrates a broad range of aniline and amide substrates with different functional groups and has been scaled up to gram level.

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