Palladium-Catalyzed Deaminative Phenanthridinone Synthesis from Aniline via C–H Bond Activation
journal contributionposted on 18.04.2016 by Subhash L. Yedage, Bhalchandra M. Bhanage
Any type of content formally published in an academic journal, usually following a peer-review process.
This work reports palladium-catalyzed phenanthridinone synthesis using the coupling of aniline and amide by formation of C–C and C–N bonds in a one-pot fashion via dual C–H bond activation. It involves simultaneous cleavage of four bonds and the formation of two new bonds. The present protocol is ligand-free, takes place under mild reaction conditions, and is environmentally benign as nitrogen gas and water are the only side products. This transformation demonstrates a broad range of aniline and amide substrates with different functional groups and has been scaled up to gram level.