Palladium-Catalyzed Aerobic Intramolecular Aminoacetoxylation of Alkenes Enabled by Catalytic Nitrate
journal contributionposted on 18.10.2016 by Jiaming Li, Robert H. Grubbs, Brian M. Stoltz
Any type of content formally published in an academic journal, usually following a peer-review process.
A mild aerobic intramolecular aminoacetoxylation method for the synthesis of pyrrolidine and indoline derivatives was achieved using molecular oxygen as the oxidant. A catalytic NOx species acts as an electron transfer mediator to access a high-valent palladium intermediate as the presumed active oxidant.