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Identification Of Potential Cytotoxic Inhibitors From Physalis Minima

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journal contribution
posted on 12.08.2019 by Viet Cuong Le Canh, Vinh Le Ba, Pham Thi Hai Yen, Lien Le Thi, Pham Thi Thuy Hoai, Ton That Huu Dat, Do Thi Thao, Long Giang Bach, Young Ho Kim, Hoang Le Tuan Anh

A phytochemical investigation of Physalis minima led to the isolation of six withanolides, including withanolide E (1), withaperuvin C (2), 4β-hydroxywithanolide E (3), 28-hydroxywithaperuvin C (4), physaperuvin G (5), and 4-deoxywithaperuvin (6). Their chemical structures were elucidated by 1 D-NMR and 2 D-NMR data, as well as comparison with the data reported in the literature. All isolated compounds were evaluated for their cytotoxic activity against HepG2, SK-LU-1, and MCF7 cancer cell lines. As the obtained results, compounds 1 and 3 displayed the strongest cytotoxicity against HepG2, SK-LU-1, and MCF7 cell lines with IC50 value ranging from 0.051 ± 0.004 to 0.86 ± 0.09 μg/mL.