Hypatulins A and B, Meroterpenes from Hypericum patulum
journal contributionposted on 28.09.2016 by Naonobu Tanaka, Yuki Yano, Yutaka Tatano, Yoshiki Kashiwada
Any type of content formally published in an academic journal, usually following a peer-review process.
Two novel prenylated benzophenone related meroterpenes, hypatulins A (1) and B (2), were isolated from the leaves of Hypericum patulum. The structures of 1 and 2 were assigned by spectroscopic analysis, chemical conversion, and calculations of the ECD (electron circular dichroism) spectra. Hypatulin A (1) had a unique densely substituted tricyclic octahydro-1,5-methanopentalene core, while hypatulin B (2) possessed a bicyclo[3.2.1]octane moiety. Hypatulin A (1) exhibited antimicrobacterial activity against Bacillus subtilis. A possible biogenetic pathway of the new meroterpenes 1 and 2 from a prenylated benzophenone was presented.