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Dinuclear Iron Complex-Catalyzed Cross-Coupling of Primary Alkyl Fluorides with Aryl Grignard Reagents

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journal contribution
posted on 24.09.2012 by Zhenbo Mo, Qiang Zhang, Liang Deng
Iron-catalyzed cross-coupling of nonactivated primary alkyl fluorides with aryl Grignard reagents has been achieved by using the low-coordinate dinuclear iron complex [(IPr2Me2)­Fe­(μ2-NDipp)2Fe­(IPr2Me2)] as the catalyst. This iron-catalyzed C­(sp3)–F bond arylation reaction is applicable to a variety of aryl Grignard reagents and primary alkyl fluorides. The product pattern suggests the involvement of a radical-type mechanism for its C–F bond scission step.