Dinuclear Iron Complex-Catalyzed Cross-Coupling of Primary Alkyl Fluorides with Aryl Grignard Reagents
journal contributionposted on 24.09.2012 by Zhenbo Mo, Qiang Zhang, Liang Deng
Any type of content formally published in an academic journal, usually following a peer-review process.
Iron-catalyzed cross-coupling of nonactivated primary alkyl fluorides with aryl Grignard reagents has been achieved by using the low-coordinate dinuclear iron complex [(IPr2Me2)Fe(μ2-NDipp)2Fe(IPr2Me2)] as the catalyst. This iron-catalyzed C(sp3)–F bond arylation reaction is applicable to a variety of aryl Grignard reagents and primary alkyl fluorides. The product pattern suggests the involvement of a radical-type mechanism for its C–F bond scission step.