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Decarboxylative Acylation of Cyclic Enamides with α‑Oxocarboxylic Acids by Palladium-Catalyzed C–H Activation at Room Temperature

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journal contribution
posted on 20.02.2016, 12:29 by Hua Wang, Li-Na Guo, Xin-Hua Duan
An efficient catalytic decarboxylative acylation of unactivated sp2 (alkenyl) C–H bonds has been developed. Various substituted α-oxocarboxylic acids with different electronic properties react under mild conditions to afford a diverse range of β-acyl enamide products in good yields. The reaction is proposed to proceed via a cyclic vinylpalladium intermediate, facilitating the decarboxylative dehydrogenative process with enamide coupling partners.

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