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DSA:  A New Internal Standard for NMR Studies in Aqueous Solution

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journal contribution
posted on 16.08.2003 by James S. Nowick, Omid Khakshoor, Mehrnoosh Hashemzadeh, Justin O. Brower
The widely used internal standard for NMR studies in aqueous solution DSS (sodium 4,4-dimethyl-4-silapentane-1-sulfonate) can interact with cationic peptides, diminishing its value for such studies. This paper introduces DSA (4,4-dimethyl-4-silapentane-1-ammonium trifluoroacetate) as a new internal standard that does not suffer from this problem.