ja311688g_si_001.pdf (815.32 kB)

Activatable Rotor for Quantifying Lysosomal Viscosity in Living Cells

Download (815.32 kB)
journal contribution
posted on 19.02.2016 by Lu Wang, Yi Xiao, Wenming Tian, Liezheng Deng
We have developed Lyso-V, the first fluorescent probe of lysosomal viscosity. Because of its lysosome-actived fluorescence characteristics, Lyso-V has proved to be an ideal lysosomal tracer with high spatial and temporal resolution under laser confocal microscopy. More importantly, Lyso-V shows its practical applicability in real-time quantification of lysosomal viscosity changes in live cells through fluorescence lifetime imaging microscopy.

History

Exports