pKa per atom and/or group of the whole molecule in amide of both its hydrolytic forms of amygdalin

article - DOI: 10.2174/1871520620999201103201008
monograph - DOI: 10.5281/zenodo.7295357 | ISBN: 978-619-91534-4-4
ATLAS - presentation of the finale information in the most applied and convenient form of application - DOI: 10.5281/zenodo.8009390 | ISBN: 978-619-91534-5-1

...Based on the definition of pKa, namely that it is inversely proportional to the "strength" of the acid (or acid residue) and the degree of more complete dissociation, it follows that HF(A) is more alkaline than HF(B), relative to the major hydrolytically active groups (-[C=O]-NH₃⁺ и –[C=O⁺H]-NH₂).

HF (B) has a change in the hydrolytically active hydroxyl groups of the glycocidal nuclei. From there, the internal polarization of the molecule also grows, which is also confirmed by the higher dipole moment (Fig.4) with respect to HF(A). It is important to note that this does not compare the dipole moments in the molecule itself with that of the molecule and the solvated volume around it. These are two different dimensions in which external factors are crucial. In our case, even with constant temperature and acidity, the molecule is also affected by other ions and molecules, and in some cases by mechanical effects (including movement of blood, cerebrospinal fluid, lymph, tissue and intercellular fluids)....