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p38, PI3K and ROCK inhibition modulates signalling in alveolar macrophages.

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posted on 28.09.2016, 17:38 authored by Martin A. Bewley, Kylie B. R. Belchamber, Kirandeep K. Chana, Richard C. Budd, Gavin Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling, Iain Kilty, Louise E. Donnelly, Peter J. Barnes, Dave Singh, Moira K. B. Whyte, David H. Dockrell

(A-F) COPD alveolar macrophages (AM) were pre-treated with the designated concentrations of SCIO469 (A) VX745 (B), NVS-PI3K-2/3/5 (C-E), or PF4950834 (F), were then challenged with S. pneumoniae for 6 h, before cells were lysed and probed for either p-HSP27 (A-B), p-AKT (C-E), or p-MLC (F). Plots are representative of three independent experiments and densitometry from all three experiments are shown, * = p<0.05, ** = p<0.01, ANOVA with Dunnetts post-test vs control.

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