modified intermolecular cationic (2+2) RXN

This is an example of a modified intermolecular cationic 2+2 cycloaddition reaction.

This is intended for use in biorthogonal chemistry, and was envisioned to get around the larger ring sizes that are typically seen in the in vivo "click" chemistry used at this time.

Potential issues would be the reaction rate. Current technology utilizes driving forces that increase the rate of the reaction, therefore the rate of these reactions would need to be considered prior to incorporation into a bio-orthogonal process.

Advantages: the introduction of Si in drugs which need to cross the blood brain barrier has been demonstrated in recent literature, as such the incorporation of Si groups on components that are meant to be used in bio-orthogonal chemistry could be beneficial.

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This idea looks at a potential way to incorporate smaller ring sizes in the "click" components of bio-orthogonal chemistry, as well as incorporating exotic functioanlity to enhance the chemistry once in the body.

see:

Synthesis of Si containing Dopamine . Jamie Boss. figshare.
http://dx.doi.org/10.6084/m9.figshare.651728Retrieved 19:58, Mar 17, 2013 (GMT)

for a list of preliminary references and other ideas realted to the incorporation of Si in pharmaceuticals meant to cross the blood brain barrier.

If you have any questions or concerns about this idea/project you may contact me at:

Jamie@itsmoleculardesign.com