mRNA expression levels of selected genes in the 6h-DEGs and 9h-DEGs after ATF6α ectopic expression.

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posted on 2024-10-28, 17:33 authored by Ju Won Kim, So-Hyun Bae, Yesol Moon, Eun Kyung Kim, Yongjin Kim, Yun Gyu Park, Mi-Ryung Han, Jeongwon Sohn

(A, B) MCF-7 cells were transfected with ATF6α cDNA or an empty vector DNA as a control. RT-PCR was conducted to assess the mRNA levels of the indicated genes selected from the 6h-DEGs (A) or 9h-DEGs (B) in MCF-7 cells after ATF6α ectopic expression. Data represent three independent experiments with similar results. Ctrl, control; ATF6 O/E, ATF6α overexpression.

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various analyses highlighted unfolded protein response lower fold change false discovery rate drives endoplasmic reticulum differentially expressed genes conducting separate investigations upstream regulator analysis gene network analysis breast cancer cells atf6 &# 945 canonical pathway analysis distinct cell types induced cellular senescence ectopic expression resulted cellular senescence induced exploring cell type stressor inducing senescence conducted transcriptomic analysis er stress pathway transcriptomic analysis ectopic expression cellular senescence cell type 7 cells &# 8216 cell viability cell death transcriptomic profile senescence stages ddit3 pathway xlink ">validation reveal validation confirmed temporal progression targets identified study contributes strongly associated specific responses rna interference processes related potential necessity particular emphasis molecular mechanism il6 among employing criteria bb among 9 hours 9 hour

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mRNA expression levels of selected genes in the 6h-DEGs and 9h-DEGs after ATF6α ectopic expression.

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