cc4821 lineage/sublineage distribution of fluoroquinolone resistance-associated gyrA alleles and penA alleles associated with reduced penicillin susceptibility.

gyrA alleles were considered to be associated with fluoroquinolone resistance (MIC ≥ 0.03 mg/L) if they possessed mutations affecting residues T91 or D95 of the corresponding peptide. penA alleles were considered to be associated with reduced penicillin susceptibility (0.094 to 1 mg/L) if they encoded the following mutations: F504L, A510V, I515V, H541N and I566V.