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syd-2 and cdk-5 regulate the polarized distribution of neuropeptides through separate genetic pathways.

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posted on 19.02.2013, 16:31 by Patricia R. Goodwin, Peter Juo

(A) Schematic diagram of a DB motor neuron (top panel). The boxed region denotes that the axon was imaged for panels (A–C). Representative images of INS-22::Venus in the axons of wild type, syd-2(ok217), cdk-5(gm336), and syd-2(ok217);cdk-5(gm336) double mutant animals (bottom panel). (B–C) Quantification of INS-22::Venus puncta intensity (B) and density (C) in the axons of wild type (n = 32), syd-2(ok217)(n = 24), cdk-5(gm336)(n = 35), and syd-2;cdk-5 double mutant (n = 19) animals. (D) Schematic diagram of a DB motor neuron (top panel). The boxed region denotes that the dendrite was imaged for panels D-F. Representative images of INS-22::Venus in the dendrites of wild type, syd-2(ok217), cdk-5(gm336), and syd-2(ok217);cdk-5(gm336) double mutant animals (bottom panel). (E–F) Quantification of INS-22::Venus puncta intensity (E) and density (F) in the dendrites of wild type(n = 44), syd-2(ok217)(n = 26), cdk-5(gm336)(n = 31), and syd-2;cdk-5 double mutant (n = 32) animals. Values that differ significantly (Tukey-Kramer) from wild type (marked by asterisks above each bar) or from other genotypes (comparisons marked by brackets) are denoted on the graphs (#p≤0.05, *p≤0.01, **p≤0.001). Values that did not differ significantly (p>0.05) are denoted by n.s.

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