## p-STAT5^{Tyr694} and p-STAT3^{Tyr705} expression upon GH treatment compared to control mice.

**A** Western Blot of p-STAT5^{Tyr694} expression in *Stat5ab ^{+/+}* (n = 2),

*Stat5ab*(n = 2) and

^{+/Δ}*Stat5ab*(n = 2) livers of GH treated and control mice. HSC70 is shown as loading control.

^{Δ/Δ}**B**IHC of p-STAT5

^{Tyr694}in sections of the livers (n = 3) used in A. Red, AEC; blue, hematoxylin. Size bar: 100 µm. High magnifications (60x) are shown in insets.

**C**Quantification of p-STAT5

^{Tyr694}levels from Western blots (grey) by densitometric scanning and IHC (magenta) using the HistoQuest software (

*Stat5ab*, control; number of cells n = 3276, GH; number of cells n = 2286;

^{+/+}*Stat5ab*control; number of cells n = 2577, GH; number of cells n = 3549;

^{+/Δ}*Stat5ab*control; number of cells n = 3299, GH; number of cells n = 2200). The highest arbitrary expression values from A and B were set to 100 for direct comparison.

^{Δ/Δ}**D**Western blot of p-STAT3

^{Tyr705}expression in

*Stat5ab*(n = 2),

^{+/+}*Stat5ab*(n = 2) and

^{+/Δ}*Stat5ab*(n = 2) livers of GH treated and control mice. HSC70 is shown as loading control.

^{Δ/Δ}**E**IHC of p-STAT3

^{Tyr705}in sections of the livers (n = 3) used in D. Red, AEC; blue, hematoxylin. Size bar: 100 µm. High magnifications are shown in insets (60x).

**F**Quantification of p-STAT3

^{Tyr705}levels from Western blots (grey) by densitometric scanning and IHC (magenta) using the HistoQuest software (

*Stat5ab*, control; number of cells n = 2634, GH; number of cells n = 2286;

^{+/+}*Stat5ab*control; number of cells n = 22230, GH n = 2562;

^{+/Δ}*Stat5ab*control; number of cells n = 2414, GH n = 2716). The highest arbitrary expression values from A and B were set to 100 for direct comparison.

^{Δ/Δ}