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pDCs are required for proper inflammatory responses during Chlamydia pneumoniae infection in mice.

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posted on 31.10.2012, 00:25 authored by Timothy R. Crother, Jun Ma, Madhulika Jupelli, Norika Chiba, Shuang Chen, Anatoly Slepenkin, Randa Alsabeh, Ellena Peterson, Kenichi Shimada, Moshe Arditi

(A) C57Bl/6 mice were infected with 3.5×106 IFU CP i. t. Mice were injected i. p. with either 500 µg mAb 927 or IgG control (n = 10) every other day starting at day -1 and survival was assessed. (B–E) C57Bl/6 mice were infected with 1×106 IFU CP i. t. and were injected i. p. with either 500 µg mAb 927 or IgG control (n = 7–10) every other day. Mice were sacrificed on days 3, 5, 14, and 21 after infection. Lungs were analyzed by (B) H&E staining (100x), (C) inflammation score, (D) BALF cell count, and (E) bacterial burden. Data for all experiments shown represent at least two independent experiments (pooled together). *p<0.05, **p<0.01, ***p<0.001 (Student's t test used unless otherwise noted).

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