mycn expression is largely restricted to early time points during zebrafish development.

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posted on 2024-09-18, 17:29 authored by Rodrigo Ibarra-García-Padilla, Annika Nambiar, Thomas A. Hamre, Eileen W. Singleton, Rosa A. Uribe

A) Violin plot showing expression of mycn is restricted to progenitor and NCC populations during early timepoints. B,C) representative images of whole mount in situ hybridization against mycn at 48 hpf (B) and 72 hpf (B) Anterior is shown to the left. A (anterior), P (posterior), D (dorsal), V (ventral) axes shown in lower right corner. b = developing brain, ba = developing branchial arches, g = developing gut, e = developing eye.

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paradoxically also co overexpressing human egfp nccs give rise later give rise lapse confocal imaging derived sympathoadrenal progenitors cell types within sympathoadrenal lineage cells sympathetic nervous system early vertebrate embryogenesis promote ncc migration aberrant ncc signature div >< p abnormal sap population neural crest cells also found evidence aggressive nb progression mycn overexpressing saps revealed transient expansion neuronal differentiation markers normal ncc development phenocopying mycn overexpression vivo ncc markers sap cells vivo transient formation sympathetic nerves saps disrupts neural tube early stages sox10 mycn overexpression sap development sap ),expressing sap zebrafish led zebrafish larvae transiently expressed several diseases results suggest reporter expression pharmacological inhibition nb ).may prime including neurons including neuroblastoma help elucidate elevated expression effect overexpression displayed expanded developmental mechanisms developmental implications developing organism bmp signaling

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mycn expression is largely restricted to early time points during zebrafish development.

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