Fli-1-induced pre-T LBL perturbs thymic, splenic and bone marrow architecture.
Representative tissue sections (Haematoxylin & Eosin stain) of MigR1 and Fli-1 mice. MigR1 sections show normal organ architecture, whereas Fli-1 sections show thymus and spleen architecture effaced by small infiltrating malignant lymphocytes also present in the Fli-1 sternum. A. Thymus (x10 magnification). B. Spleen (x10 magnification). C. Sternum (x40 magnification).