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hwp1 null strains display attenuated virulence in BALB/c mice.

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posted on 08.11.2013, 03:19 by Janet F. Staab, Kausik Datta, Peter Rhee

BALB/c mice infected with hwp1Δ/Δ strains SCH1211 (n=11) or DD27-U1 (n=6) were attenuated in virulence in intravenously infected BALB/c mice. Reintroducing HWP1 at its native site in SCH1211 (HR615, n=7) did not restore full virulence of the strain to wild type levels (SC5314, n=13). The rate of survival among the strains deleted for HWP1 (SCH1211 and DD27-U1) or expressing a single allele (HR615) was statistically different (P<0.05) relative to the wild type SC5314.

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