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dsRNA-induced CXCL10 and CXCL9 in serum.

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posted on 10.04.2009 by Christiane Stahl-Hennig, Martin Eisenblätter, Edith Jasny, Tamara Rzehak, Klara Tenner-Racz, Christine Trumpfheller, Andres M. Salazar, Klaus Überla, Karen Nieto, Jürgen Kleinschmidt, Reiner Schulte, Lutz Gissmann, Martin Müller, Anna Sacher, Paul Racz, Ralph M. Steinman, Mariagrazia Uguccioni, Ralf Ignatius

(A) Mean serum levels (±SD) of CXCL10 after immunization of animals with either KLH alone (n = 4), KLH+0.5 mg/kg poly I:C (n = 4 animals), or KLH+0.5 mg/kg poly ICLC (n = 6 animals). (B) The effect of lower doses of poly ICLC on CXCL10 serum levels was assessed in two animals immunized with 0.1 mg/kg. (C) Mean serum levels (±SD) of CXCL10 after immunization of five animals per group with either KLH alone, KLH+6 mg poly IC12U, KLH+2 mg poly IC12U, or KLH+2 mg poly ICLC. (D) Serum levels of CXCL9 after immunization with either KLH alone (n = 2, dotted lines), KLH+0.5 mg/kg poly I:C (full lines, open symbols), or KLH+0.5 mg/kg poly ICLC (full lines, full symbols). Chemokine levels were determined at the indicated points in time; *, p = 0.027; **, p≤0.001.