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Without degradation, angiogenesis is inhibited at (Figure 3F).

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posted on 24.07.2009 by Amy L. Bauer, Trachette L. Jackson, Yi Jiang

(A) shows that tip cell matrix degradation promotes sprout development at by carving out a path for migration, called a vascular guidance tunnel (B). (C) depicts sprout formation and branching with ECM degradation at , a density not typically conducive to branching, suggesting that high matrix heterogeneity (D) created by tip cell degradation may be a mechanism for branching (Video S3). (E) VEGF gradient profile (pg) shows strong gradient along leading edges of sprout. Snapshots at 14 hours.

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