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Western blot analysis of PS-1 in fibroblasts from LND patients.

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posted on 2011-01-28, 00:49 authored by Tae Hyuk Kang, Ghiabe-Henri Guibinga, Theodore Friedmann

WT cells demonstrate very low levels of PS-1 processing to the N- and C-terminal fragment (NTF and CTF, respectively). In both LND cells, processing to both the NTF and CTF proteolytic products is markedly increased compared with that seen in HPRT-positive control WT human fibroblasts.