“Weighted complex V activity” as a function of “mitochondrial damage”.

Data from Table 2. (○) brain; (●) liver; (□) muscle; (■) heart.; “weighted complex V activity” is given by the fraction of complex V activity measured in the absence of DDM; “mitochondrial damage” is given by the fraction of ATPase activity sensitive to external IF1 addition in the absence of DDM. Data were fitted by the linear relationship V = V_i + α (1-V_i), where V is the Weighted complex V activity, V_i the fraction mitochondrial damage, and α the ratio between complex V activity in intact mitochondria and that in damaged ones. Here α = 0.11, which means that the complex V activity in intact mitochondria is only 11% of the activity in damaged or DDM-treated mitochondria.