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Validation of AKT subgroups in an independent dataset.

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posted on 01.07.2014, 02:52 by Anna Joy, Archana Ramesh, Ivan Smirnov, Mark Reiser, Anjan Misra, William R. Shapiro, Gordon B. Mills, Seungchan Kim, Burt G. Feuerstein

AKT pathway genes in discovery (A) and validation (B) datasets have similar patterns of expression in subgroups. Tumors in the discovery and validation set were first grouped by AKT subgroup membership then ordered by correlation coefficient. AKT gene order in the discovery set was determined by one-way hierarchical clustering and retained in the validation set. Discovery (C) and validation (D) datasets have similar DNA CNA. The percentage of patients in the discovery (A) and validation (B) datasets with copy number gains or losses in chr7, 10 and 19q is shown.

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