Vaccinia vaccination abrogates bleomycin induced pulmonary fibrosis.
A. Histological analysis of lungs of vaccinia vaccinated and mock (PBS) vaccinated mice following bleomycin administration. B. Total lung collagen concentration following bleomycin administration. C. Flow cytometry and graphical analysis of fibrocyte (CD45+, Collagen+) numbers in lungs of mice 7 days after bleomycin administration. Error bars indicate one standard deviation of the mean and (*) indicates statistical significance (p<.05) between groups. All experiments were performed at least three times, at least 10 animals per group per experiment.