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Upregulation of microglial marker CD68 in the thalamus and cerebral cortex of Cln6nclf mice.

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posted on 01.11.2013, 03:14 by Jeremy P. Morgan, Helen Magee, Andrew Wong, Tarah Nelson, Bettina Koch, Jonathan D. Cooper, Jill M. Weimer

Quantitative thresholding analysis in Cln6nclf mice was compared to age matched WT, revealing a significant increase in the expression of the microglia marker CD68 in the VPM/VPL (A), M1 (C), S1BF (B), and V1 (D) regions in the Cln6nclf mouse over WT. [Mean% immunoreactivity +/− SEM, n = 3 (*p≤0.05, **p≤0.01, ***p≤0.001, ****p≤0.0001)].