Upregulation of microglial marker CD68 in the thalamus and cerebral cortex of <i>Cln6<sup>nclf</sup></i> mice.
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posted on 2013-11-01, 03:14 authored by Jeremy P. Morgan, Helen Magee, Andrew Wong, Tarah Nelson, Bettina Koch, Jonathan D. Cooper, Jill M. Weimer<p>Quantitative thresholding analysis in <i>Cln6<sup>nclf</sup></i> mice was compared to age matched WT, revealing a significant increase in the expression of the microglia marker CD68 in the VPM/VPL (<b>A</b>), M1 (<b>C</b>), S1BF (<b>B</b>), and V1 (<b>D</b>) regions in the <i>Cln6<sup>nclf</sup></i> mouse over WT. [Mean% immunoreactivity +/− SEM, <i>n</i> = 3 (*<i>p</i>≤0.05, **<i>p</i>≤0.01, ***p≤0.001, ****<i>p</i>≤0.0001)].</p>
