Upregulation of astrocyte marker GFAP in the thalamus and cerebral cortex of <i>Cln6<sup>nclf</sup></i> mice.
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posted on 2013-11-01, 03:14 authored by Jeremy P. Morgan, Helen Magee, Andrew Wong, Tarah Nelson, Bettina Koch, Jonathan D. Cooper, Jill M. Weimer<p>(<b>A</b>) Quantitative thresholding analysis revealed a significant increase in the expression of astrocytic markers in the <i>Cln6<sup>nclf</sup></i> mouse at 4 months in the thalamus. (<b>B–C</b>) Elevations in astrocytic activation, marked by GFAP labeling, became apparent in the S1BF region at 4 months and in the V1 region of the cerebral cortex at 6 months in the <i>Cln6<sup>nclf</sup></i> mouse. [Mean% immunoreactivity +/− SEM, <i>n</i> = 3 (*<i>p</i>≤0.05, **<i>p</i>≤0.01, ***<i>p</i>≤0.0001)].</p>
