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Typical desialylated and α-1,6-fucosidase digested N-glycan profiles from gastric tumor and adjacent non-tumor tissue proteins.

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posted on 2014-04-14, 02:43 authored by Yun-Peng Zhao, Xin-Yun Xu, Meng Fang, Hao Wang, Qing You, Chang-Hong Yi, Jun Ji, Xing Gu, Ping-Ting Zhou, Cheng Cheng, Chun-Fang Gao

(A) The five panels (from top to bottom) are desialylated N-glycan profiles from serum as reference, desialylated N-glycan profiles from tumor tissues, desialylated N-glycan profiles from tumor tissues treated with α-1,6-fucosidase digestion, desialylated N-glycan profiles from adjacent non-tumor tissues, and desialylated N-glycan profiles from adjacent non-tumor tissues treated with α-1,6-fucosidase digestion. The arrow lines indicate the changes of N-glycan peaks treated with α-1,6-fucosidase digestion. Peak6 and peak7 remove forward after α-1,6-fucosidase digestion, which reveale that peak5, 6 and 7 have the same structures as in the serum, and peak6 and peak7 are α-1,6-fucosylated N-glycans. (B) The value of peak6/peak5 is decreased in tumor tissues, but the difference is not statistically significant. Error bars represent 95%CI for means. (C) The value of peak7/peak5 is also decreased in tumor tissues, but the difference is not statistically significant.

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