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Two-way sensitivity analysis: serology versus culture for diagnosis of drug-sensitive TB.

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posted on 20.02.2013 by David W. Dowdy, Karen R. Steingart, Madhukar Pai

For the incremental cost-effectiveness ratio (ICER) to be more favorable for serology than for TB culture using commercial liquid media (MGIT) in the base-case scenario (73% sensitivity and 99% specificity), the sensitivity and specificity of serology for smear-negative TB must achieve values above the primary line. The estimated sensitivity and specificity of serology in the base case are 59% and 87%, respectively [14].

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