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Two-step criteria to define (likely) causes for LRI hospitalization clusters detected in 1999–2006.

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posted on 29.04.2010 by Cees C. van den Wijngaard, Liselotte van Asten, Wilfrid van Pelt, Gerda Doornbos, Nico J. D. Nagelkerke, Gé A. Donker, Wim van der Hoek, Marion P. G. Koopmans

* As evaluated by the right-sided Fisher's exact test for 2×2 Tables (alpha≤0.01) of hospitalizations within vs hospitalizations outside of the cluster-signal. The proportion of hospitalizations with a specific characteristic (e.g. legionnaires' disease as discharge diagnoses, or age 20–49 yrs) can be significantly higher among hospitalizations within the cluster-signal than the proportion outside of the cluster-signal. ** For the ILI-cluster-signals we could only use 4 major regions as spatial resolution. Overlap in time between LRI and ILI-cluster-signals was defined as occurrence of weekly ILI-cluster-signals within 2 weeks (+/−) around LRI-cluster-signals. ***The annual influenza season was defined as all weeks with a national weekly ILI-incidence ≥3 per 10.000 pop. **** Possibly unreported/undetected local LRI-outbreaks by undetected pathogens.

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