Figure_4.tif (1.58 MB)
Translocation of GFP-tagged RasGRP1 in living cells after treatment with PMA or I3A.
figure
posted on 2013-08-21, 01:37 authored by Xiaohua Song, Ana Lopez-Campistrous, Lucy Sun, Nancy A. Dower, Noemi Kedei, Jing Yang, Jessica S. Kelsey, Nancy E. Lewin, Tim E. Esch, Peter M. Blumberg, James C. StoneCells expressing GFP-RasGRP1 were treated with 1000 nM PMA or I3A. The translocation pattern was examined in live cells as a function of time. The results of duplicate experiments with I3A are shown. The images shown are representative of four independent experiments. The scale bar represents 10 µm.
History
Usage metrics
Categories
Keywords
BiochemistryBiomacromolecule-ligand interactionsBlood chemistrychemical biologydrug discoveryenzymesproteinsSmall moleculesimmunologyImmune cellsMolecular cell biologySignal transductionSignaling cascadesERK signaling cascadeProtein kinase signaling cascadeSignaling in cellular processesProtein kinase C signalingRas signalingCell deathCell growthmedicinal chemistryhematologyHematologic cancers and related disorderslymphomasHodgkin lymphomaoncologyCancers and neoplasmsgfp-taggedrasgrp1cellspma