Figure_4.tif (1.58 MB)
Translocation of GFP-tagged RasGRP1 in living cells after treatment with PMA or I3A.
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posted on 2013-08-21, 01:37 authored by Xiaohua Song, Ana Lopez-Campistrous, Lucy Sun, Nancy A. Dower, Noemi Kedei, Jing Yang, Jessica S. Kelsey, Nancy E. Lewin, Tim E. Esch, Peter M. Blumberg, James C. StoneCells expressing GFP-RasGRP1 were treated with 1000 nM PMA or I3A. The translocation pattern was examined in live cells as a function of time. The results of duplicate experiments with I3A are shown. The images shown are representative of four independent experiments. The scale bar represents 10 µm.
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BiochemistryBiomacromolecule-ligand interactionsBlood chemistrychemical biologydrug discoveryenzymesproteinsSmall moleculesimmunologyImmune cellsMolecular cell biologySignal transductionSignaling cascadesERK signaling cascadeProtein kinase signaling cascadeSignaling in cellular processesProtein kinase C signalingRas signalingCell deathCell growthmedicinal chemistryhematologyHematologic cancers and related disorderslymphomasHodgkin lymphomaoncologyCancers and neoplasmsgfp-taggedrasgrp1cellspma
