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Transcriptional state transition of loci in various gene ontologies.

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posted on 19.08.2011, 01:09 by Jonathan L. Golob, Roshan M. Kumar, Matthew G. Guenther, Lil M. Pabon, Gabriel A. Pratt, Jeanne F. Loring, Louise C. Laurent, Richard A. Young, Charles E. Murry

(A) Loci with an annotated in multicellular organismal development (GO:0007275) are more likely than the whole genome to start paused and have a greater number of loci (15.4% vs 11.9% overall) transitioning state. (B) Loci annotated for translation elongation (GO:0006414), a housekeeping function, tend to start and end as active, with no loci changing state. (C) Loci annotated for being in the ATP generating proton-pump (GO:0046961), another housekeeping function, also are greatly enriched for those starting and ending as active. A small number of loci (5.3% in this ontogeny) are transcriptionally activating from paused to active. (D) Loci annotated as regulators of heart contraction (GO:0008016), are highly enriched for those starting paused, with loci transcriptionally activating or priming for mesodermal or later productive transcription. (E) Loci annotated for neurotransmitter receptor activity (GO:0030594) also tend to start paused, but those loci transitioning are instead archiving to silent, reflecting a commitment away from ectodermal lineages, such as neurons. (F) Loci annotated for keratinization (GO:0031424) also tend to start paused, with those transitioning archiving to silent, reflecting a commitment away from ectodermal lineages, such as skin.

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