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Tracking of X-Sight-labeled MSCs in control and chagasic mice 2 or 15 days after cell transplantation.

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posted on 19.02.2013, 18:41 authored by Jasmin, Linda A. Jelicks, Wade Koba, Herbert B. Tanowitz, Rosália Mendez-Otero, Antonio C. Campos de Carvalho, David C. Spray

The cells were intravenously injected (tail vein) in control and chagasic animals 1 month after infection for tracking by IVIS. (A) Representative images showing the distribution of transplanted MSCs viewed from in the ventral surface of the body. (B) Images of ex vivo organs showing the distribution of labeled MSCs. Note the majority of the signal is localized in the lung, liver and spleen of the animals. (C–H) Quantification of fluorescence intensity of ex vivo organs shown in images (B). The evaluated organs were (C) heart, (D) bladder, (E) lung, (F) liver, (G) spleen and (H) kidney. P<0.05.