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Toxicity and anti-vector cellular immune responses.

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posted on 2009-03-31, 00:51 authored by Eric A. Weaver, Pramod N. Nehete, Stephanie S. Buchl, Julien S. Senac, Donna Palmer, Philip Ng, K. Jagannadha Sastry, Michael A. Barry

Toxicity and the induction of anti-vector cellular immune responses were measured. Liver toxicity is expressed as a measured of ALT expression 48 hours after i.m. (A) and i.v. (B) injection. Anti-adenovirus cellular responses were measured 4 wks after i.m. (C) and i.v. (D) injections. Naïve BALB/c splenocytes infected with wild-type Ad5 were used as antigen presenting cells and were co-cultured with splenocyted from immunized mice. Anti-Ad5 cellular responses were measured by ELISPOT. Data represent groups of 5 mice and error bars indicate standard error. The data were analyzed by one-way ANOVA (* = p<0.05 and *** = p<0.001).


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