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Tonic applied depolarization and AMPA receptor activation are unable to significantly elevate the frequency.

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posted on 19.07.2013 by Joon Ha, Alexey Kuznetsov

(A) An applied current is injected into the soma for 1000 ms at an intensity slightly lower than that causing blockade of oscillations (700 pA). (B) Tonic AMPA receptor stimulation causes complex oscillations and, consequently, only reduces the frequency. (C) and (D) The dependence of the frequency on the applied current and AMPA maximal conductance, respectively. The oscillations are blocked at the end of each curve.